1. Stewie’s First Word
While at church, when Stewie learns that the Wi-Fi is bad and they are not giving out cookies, he drops an F-bomb, which everyone at church somehow hears, causing Lois to be shunned by the entire town. Brian and Stewie begin to consider it had to do with him shouting his true feelings. Wondering where Stewie could have heard what she believes is his first word, Lois initially suspects television, but Brian points out that all Stewie watches now is Caillou, which she learns has no curse words, just odd dialogue. She then guesses Peter to be the source of Stewie swearing, and waxes the stairs for him to fall down (again), though Peter only shouts proper terms as he has been hanging out with Boris. When Lois eventually discovers herself to be the root of Stewie's profanity, she goes to a rehabilitation facility, where she gets scolded for using the F-word as her meditation mantra, and decides to accept her swearing habits and states she is fine how she is.
2. The Talented Mr. Stewie
Stewie dumps Rupert when he learns he used to belong to Chris. He tries to get revenge by getting a new teddy bear and then a toy giraffe, but neither helps him feel better. After taking a spiritual journey, Stewie concludes he must kill Chris and Rupert. Stewie lures Chris to a lake house he rented and knocks him out. He fights Chris in the rowboat while discussing The Talented Mr. Ripley and that it is not an Alfred Hitchcock film. Stewie knocks Chris out and into the water. Using the nanny cam he put in Rupert earlier to keep an eye on him and Chris, Stewie learns Chris was going to give him back. After a few unsuccessful tries, Stewie manages to save Chris. As the latter recovers in the hospital, they agree to never reveal what happened.
3. Boys & Squirrels
Peter chops down a tree with a chainsaw, leaving a young squirrel orphaned, which Chris and Stewie decide to raise together. Peter goes to Dr. Hartman and gets chiropractic therapy, making him taller.
4. CutawayLand
While spending a day on the beach with their children, Lois and Peter try to find a secluded spot to have sex, but keep getting interrupted by the children. At home, when Brian and the kids annoy them again, the two yell at them and do a cutaway joke simultaneously, causing them to be sent into the cutaway. They soon understand they have been teleported to an alternate universe where all the show's cutaways reside and new ones are made, which Lois dubs "Cutawayland". They also learn it takes two people to send them to Cutawayland and one person to move them around cutaways by creating one or mentioning a previous one. While Brian and the kids call Joe to find Peter and Lois, the two enjoy their time in Cutawayland, until the latter decides she wants to return to their family and persuades Peter to do the same. However, they instead cause the rest of the family to be teleported into Cutawayland as well.
5. La Famiglia Guy
The Griffins attend Susie's christening at an Italian restaurant, during which Joe asks Peter to be Susie's godfather. Mistaking the term for the title used by the Mafia, Peter begins acting like a Don, and scares the restaurant staff, who give him everything he wants. He later recruits Joe, Quagmire, and Cleveland into his crew, and together they operate various rackets in Quahog, until running afoul of the real Mafia. Meanwhile, Chris, who has been sent by Peter to Italy, finds love and tries to start a new life, only for his wife to die in a car bombing after Peter tries to call Chris to tell him the Mafia might go after him separately. To take down the Mafia bosses, Joe devises a plan to have Peter wear a wire while attending a meeting with them in Quahog, but he blows his cover when the Dons suggest going out for karaoke.
6. Meg's Wedding
Unable to secure a date for a school dance, Meg instead hangs out at the bowling alley with her friend and shoe rental guy Bruce. They quickly build up a relationship, but Lois is concerned that Bruce, who has always been shown to be attracted to men, does not love her, and tries to convince Meg to break up with him. Under pressure from his parents, Bruce later proposes to Meg, who accepts. At Bruce and Meg's wedding, Lois finally decides to accept their relationship, but Meg realizes Bruce is gay and that he is not happy, and encourages him to reveal his homosexuality to his parents. Bruce then proposes to his boyfriend Jeffrey, and the two get married by Peter after the priest refused to do so.
7. Wild Wild West
Lois and Peter are divided by differing views on who the next Mayor of Quahog should be. Upset at Lois' first choice, Peter seeks out the late Mayor Adam West's cousin, Wild Wild West.
8. Pawtucket Pat
Brian's new job as a journalist leads him to uncover that Pawtucket Pat, Quahog's hero and brewery founder, took part in racist actions against Native Americans; the town becomes divided on whether or not to remove the statue that commemorates him
9. The First No L
When the family fails to help Lois with the Christmas shopping, she walks out on the family and the Griffins must try to save Christmas on their own.
10. Fecal Matters
When Peter makes it through a bad flu season without getting sick, the hospital asks him to volunteer as a nurse, but he finds himself at a crossroads when his mortal enemy, The Giant Chicken, is admitted to the ER. Meanwhile, Brian receives his genetic test results and learns he is part cat, causing him to have an identity crisis.
11. Boy's Best Friend
Brian bonds with his new girlfriend's son; Peter, Quagmire and Cleveland take a joy ride in Joe's new classic corvette.
12. And Then There's Fraud
After attending a baseball game, Peter and Chris are inspired to start a memorabilia business. Meanwhile, Stewie tries to combat aging by getting plastic surgery, but ends up taking it too far.
13. PeTerminator
Stewie designs a "Terminator" Peter robot to destroy Lois for trying to feed him broccoli, but when things don't go according to plan, Stewie and Brian must go on a Terminator-esque mission to save Stewie's life.
14. The Marrying Kind
Stewie gets a mail order bride from Ukraine and experiences domestic life. Meanwhile, Peter and Chris become addicted to free hotel breakfast buffets.
15. Customer of the Week
After feeling unappreciated by her family, Lois taps into her villainous side and attempts to win "Best Customer" at her favorite coffee shop.
16. Who's Brian Now?
Brian has a microchip that reveals he had a family before the Griffins, when he then seeks out. After meeting the richer, smarter Hendersons, Brian struggles to enjoy his life with the Griffins as much as he once did.
17. Young Parent Trap
Lois and Peter are mistaken for "young parents" by another couple at Stewie's school and invited to live in a millennial apartment complex, leaving Meg and Chris home alone.
18. Meg Goes to College
Meg deals with a college admissions scandal, while Brian embarks on a fitness journey.
19. Family Cat
Brian tries to convince The Griffins that their new adopted cat, Pouncy, is evil.
20. Tales of Former Sports Glory
The guys regale each other with stories of youthful athletic accomplishments. Cleveland was a teenage baseball player from Cuba, Quagmire was a bad boy tennis superstar from New York and Peter was an underdog boxer from Philadelphia.